Sermorelin is a synthetic research peptide corresponding to the 1–29 amino acid fragment of endogenous Growth Hormone-Releasing Hormone (GHRH). Despite being a truncated form, this segment retains full biological activity and is commonly used in in vitro and in vivo studies to investigate the regulation of growth hormone (GH) secretionand its downstream effects on cellular growth, metabolism, and recovery.
Mechanism of Action:
-
Receptor Binding
Sermorelin selectively binds to the GHRH receptor (GHRH-R) on anterior pituitary cells, mimicking the natural action of endogenous GHRH in test models. -
Signal Activation
Receptor activation initiates the cAMP-PKA intracellular signaling cascade, resulting in the transcription and release of growth hormone (GH) from pituitary tissue. -
IGF-1 Axis Stimulation
Increased GH levels subsequently stimulate hepatocyte cultures or liver models to produce Insulin-like Growth Factor 1 (IGF-1), which is involved in cell proliferation, anabolism, and lipid metabolism under experimental condition
Reviews
There are no reviews yet.